BASIC SCIENCE INVESTIGATIONS Intense 18F-FDG Uptake in Brown Fat Can Be Reduced Pharmacologically

Physiologic 18F-FDG uptake in areas of supraclavicular fat in hu-mans (“USA-Fat”) has recently been recognized as 18F-FDG up-take in apparent brown adipose tissue (BAT) using fused PET/CT technology. In this study, we evaluated 18F-FDG uptake in BAT of rats to determine whether pharmacologic or physiologic interven-tions affect the uptake, knowing that BAT has a high density of adrenergic innervat…