Vulnerability of SRSF2 -mutated chronic myelomonocytic leuke…
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- DOI 10.1182/bloodadvances.2025017005
- PMID https://pubmed.ncbi.nlm.nih.gov/41346291
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/12874312
- OpenAlex ID W4417028896
- Type Article
- Language EN
- Published 05 Dec 2025
- Volume 10 (3)
- Pages 710–724
- Source Blood Advances
- Publisher Elsevier BV
- FWCI 0.60
- Countries 2
- Institutions 3
- Added 05 Dec 2025
- Updated 31 Oct 2026
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Vulnerability of SRSF2 -mutated chronic myelomonocytic leukemia to perturbation of the cGAS-STING pathway
Article 2025 EN Gold
ABSTRACT: Chronic myelomonocytic leukemia (CMML) is characterized by monocytosis in blood and bone marrow and natural progression to acute myeloid leukemia (AML) in ≤30% of patients. The mutation landscape of CMML has been reported, and animal models that recapitulate its clinicopathologic features and progression are needed. We report a CMML zebrafish model based on transgenic SRSF2P95H expressio…
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15
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
15 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Yanan Chen | University of Hong Kong (HK) | |
| 2 | Koon Chuen Chan | University of Hong Kong (HK) | |
| 3 | Chun‐Fung Sin | University of Hong Kong (HK) | |
| 4 | Lichuan Zheng | University of Hong Kong (HK) | |
| 5 | Dandan Wang | University of Hong Kong (HK) | |
| 6 | Lingge Tu | University of Hong Kong (HK) | — |
| 7 | Fangfang He | University of Hong Kong (HK) | |
| 8 | Wan Hei Jeffrey Hui | University of Hong Kong (HK) | — |
| 9 | Hoi Ki Leung | University of Hong Kong (HK) | — |
| 10 | Sy Ha | University of Hong Kong (HK) | |
| 11 | Sze Pui Tsui | Queen Mary Hospital (CN) University of Hong Kong (HK) | — |
| 12 | Hoi yi Chan | University of Hong Kong (HK) | — |
| 13 | Alvin Chun Hang Ma | Hong Kong Polytechnic Universi… (HK) | |
| 14 | Anskar YH Leung Corresponding | University of Hong Kong (HK) | — |
| 15 | Xuan Sun Corresponding | University of Hong Kong (HK) |
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