Modeling the window of implantation: insights from endometri…

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Modeling the window of implantation: insights from endometrial biopsy and menstrual blood-derived organoids and endometrial stromal cells

Article 2025 EN Gold

Abstract STUDY QUESTION Can menstrual blood-derived organoids (MB-organoids) and human endometrial stromal cells (MB-ESCs) serve as a physiologically relevant, non-invasive model for studying endometrial function and hormonal response? SUMMARY ANSWER MB-organoids and ESCs recapitulate key structural and functional features of the endometrium, responding to hormonal stimulation in a manner comparab…

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8 authors
#AuthorInstitutionsORCID
1 Francesca Paola Luongo University of Siena (IT)
2 Irene Ortega Baño University of Siena (IT) —
3 Giuseppe Belmonte University of Siena (IT) —
4 Mariangela Gentile University of Siena (IT)
5 Eugenio Paccagnini University of Siena (IT)
6 Andres Salumets Karolinska University Hospital (SE) Karolinska Institutet (SE) +2
7 Paola Piomboni Corresponding University of Siena (IT)
8 Alice Luddi Corresponding University of Siena (IT)

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