Flexible and efficient count-distribution and mixed-model methods for eQTL mapping with quasar

Abstract Identifying genetic variants that affect gene expression, expression quantitative trait loci (eQTLs), is a major focus of modern genomics. Today, various methods exist for eQTL mapping, each using different statistical and methodological approaches. However, it is unclear which approaches lead to better performance, and challenges, particularly scalability as datasets continue to increase…