ALK/ATR combination therapy is effective in neuroblastoma mo…
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- DOI 10.1101/2025.07.17.665300
- OpenAlex ID W4412526905
- Type Preprint
- Language EN
- Published 21 Jul 2025
- Source bioRxiv (Cold Spring Harbor Laboratory)
- Publisher Cold Spring Harbor Laboratory
- Countries 2
- Institutions 3
- Added 10 Oct 2025
- Updated 04 Oct 2026
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ALK/ATR combination therapy is effective in neuroblastoma mouse tumors driven by MYCN
Preprint 2025 EN Green
Summary paragraph One of the key features of high-risk neuroblastoma (NB) is MYCN -amplification. While MYCN is still regarded as therapeutically challenging despite intensive efforts to find targeting compounds, inhibitors against Anaplastic Lymphoma Kinase (ALK) are now being evaluated among ALK-driven NB patients with promising results. There is a pressing need to find alternative treatment reg…
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12 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Marcus Borenäs | University of Gothenburg (SE) | |
| 2 | Dan Emil Lind | University of Gothenburg (SE) | |
| 3 | Adam Lehnberg | University of Gothenburg (SE) | — |
| 4 | Edit Zenténius | University of Gothenburg (SE) | — |
| 5 | Matilda Esselius | University of Gothenburg (SE) | — |
| 6 | Eva Jennische | University of Gothenburg (SE) | |
| 7 | Joel Johansson | University of Gothenburg (SE) | — |
| 8 | Jikui Guan | University of Gothenburg (SE) | |
| 9 | Agata Aniszewska | University of Gothenburg (SE) | |
| 10 | Jimmy Van den Eynden | Ghent University (BE) Cancer Research Institute Ghen… (BE) | |
| 11 | Bengt Hallberg | University of Gothenburg (SE) | |
| 12 | Ruth Helen Palmer Corresponding | University of Gothenburg (SE) |
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