Integrative bioinformatics and machine learning identify iron metabolism genes MAP4, GPT, and HIRIP3 as diagnostic biomarkers and therapeutic targets in Alzheimer’s disease

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory impairment, and the accumulation of pathological markers such as amyloid-beta plaques and neurofibrillary tangles. Recent evidence suggests a role for dysregulated iron metabolism in the pathogenesis of AD, although the precise molecular mechanisms remain largely undefined. M…