Author response: The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision

AssessmentThis useful study by Gao et al identifies Hspa2 as a heterogeneous transcript in the early embryo and proposes a plausible mechanism showing interactions with Carm1.The authors propose that variability in HSPA2 levels among blastomeres at the 4-cell stage skews their relative contribution to the embryonic lineage.Given only 4 other heterogeneous transcripts/non-coding RNA have been propo…