Detection and Quantification of Polymorphic MICA and MICB Mo…

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Detection and Quantification of Polymorphic MICA and MICB Molecules in Immunoassays: Initial Insights

Article 2025 EN

The MICA and MICB molecules, expressed on the cell membrane in response to cellular stress or cancer transformation, pose significant challenges for immunoassays. They exhibit high sequence and structural similarity, alongside considerable allelic polymorphism, with 291 and 53 known protein sequences, respectively. Some researchers treat MICA and MICB as a unified target because of their structura…

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16 authors
#AuthorInstitutionsORCID
1 A. Yu. Stolbovaya Corresponding Research Institute of Obstetri… (RU) Russian Scientific Center of R… (RU)
2 A. A. Pinevich St Petersburg University (RU) Russian Scientific Center of R… (RU)
3 Irina Vladimirovna Gryazeva Russian Scientific Center of R… (RU)
4 И. Ю. Крутецкая Russian Scientific Center of R… (RU)
5 Gennady M. Zharinov Russian Scientific Center of R… (RU)
6 Maria A. Morozova First Pavlov State Medical Uni… (RU)
7 Aleksei Yu. Kneev Russian Scientific Center of R… (RU)
8 Терехина Лидия Александровна Russian Scientific Center of R… (RU)
9 S. A. Ishchuk Russian Scientific Center of R… (RU)
10 О. А. Шашкова Research Institute of Obstetri… (RU) Russian Scientific Center of R… (RU)
11 Вартанян Наталья Левоновна Russian Scientific Center of R… (RU)
12 М. П. Самойлович St Petersburg University (RU) Russian Scientific Center of R… (RU)
13 V. F. Bezhenar First Pavlov State Medical Uni… (RU)
14 Д. И. Соколов Research Institute of Obstetri… (RU)
15 S. А. Selkov Research Institute of Obstetri… (RU)
16 Ilya Valerevich Smirnov Corresponding Research Institute of Obstetri… (RU) Russian Scientific Center of R… (RU)

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