RUVBL1 and RUVBL2 are druggable MYCN regulators in neuroblas…
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- DOI 10.1101/2024.10.03.616410
- OpenAlex ID W4403118789
- Type Preprint
- Language EN
- Published 04 Oct 2024
- Source bioRxiv (Cold Spring Harbor Laboratory)
- Publisher Cold Spring Harbor Laboratory
- Countries 2
- Institutions 3
- Added 10 Oct 2025
- Updated 16 Oct 2026
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RUVBL1 and RUVBL2 are druggable MYCN regulators in neuroblastoma
Preprint 2024 EN Green
ABSTRACT High-risk neuroblastoma is characterized by MYCN amplification and high MYCN or MYC gene expression. These patients have a poor prognosis and there is an urgent need for more effective drugs. While strategies to develop inhibitors that directly target the MYC proteins have remained largely unsuccessful, recent preclinical studies have identified ATR, a key protein of the DNA damage respon…
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
14 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Joachim T. Siaw | Ghent University (BE) Cancer Research Institute Ghen… (BE) +1 | |
| 2 | Arne Claeys | Ghent University (BE) Cancer Research Institute Ghen… (BE) | |
| 3 | Wei‐Yun Lai | University of Gothenburg (SE) | |
| 4 | Marcus Borenäs | University of Gothenburg (SE) | |
| 5 | Elien Hilgert | Ghent University (BE) Cancer Research Institute Ghen… (BE) | |
| 6 | Sarah-Lee Bekaert | Ghent University (BE) Cancer Research Institute Ghen… (BE) | |
| 7 | Ellen Sanders | Ghent University (BE) Cancer Research Institute Ghen… (BE) | |
| 8 | İrem Kaya | — | — |
| 9 | Jo Van Dorpe | Cancer Research Institute Ghen… (BE) | |
| 10 | Frank Speleman | Ghent University (BE) Cancer Research Institute Ghen… (BE) | |
| 11 | Kaat Durinck | Ghent University (BE) Cancer Research Institute Ghen… (BE) | |
| 12 | Bengt Hallberg | University of Gothenburg (SE) | |
| 13 | Ruth Helen Palmer | University of Gothenburg (SE) | |
| 14 | Jimmy Van den Eynden Corresponding | Ghent University (BE) Cancer Research Institute Ghen… (BE) |
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