Abstract ND11: Chemoproteomic-enabled discovery of VVD-214, …
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- DOI 10.1158/1538-7445.am2024-nd11
- OpenAlex ID W4393988343
- Type Conference-abstract
- Language EN
- Published 05 Apr 2024
- Volume 84 (7_Supplement)
- Pages ND11
- Source Cancer Research
- Publisher American Association for Cancer Res…
- Countries 3
- Institutions 6
- Added 06 Apr 2024
- Updated 22 Oct 2026
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Abstract ND11: Chemoproteomic-enabled discovery of VVD-214, a synthetic lethal allosteric inhibitor of WRN helicase
Conference-abstract 2024 EN
Abstract WRN helicase is a promising target for treating cancers with microsatellite instability (MSI) due to its essential role in resolving deleterious non-canonical DNA structures that accumulate in cells with faulty mismatch repair mechanisms. Currently, there are no approved drugs directly targeting human DNA or RNA helicases, in part due to the challenging nature of developing potent and sel…
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39 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Shota Kikuchi | Vividion Therapeutics (United … (US) | |
| 2 | Piergiorgio Pettazzoni | F. Hoffmann-La Roche AG (CH) | |
| 3 | Kristen A. Baltgalvis | Vividion Therapeutics (United … (US) | |
| 4 | Kelsey N. Lamb | Vividion Therapeutics (United … (US) | |
| 5 | Kent T. Symons | Vividion Therapeutics (United … (US) | — |
| 6 | Chu-Chiao Wu | Vividion Therapeutics (United … (US) | — |
| 7 | Melissa A. Hoffman | Vividion Therapeutics (United … (US) | |
| 8 | Aaron Nathan Snead | Vividion Therapeutics (United … (US) | |
| 9 | Xiaodan Song | Vividion Therapeutics (United … (US) | — |
| 10 | Thomas Glaza | Vividion Therapeutics (United … (US) | — |
| 11 | Jason C. Green | Vividion Therapeutics (United … (US) | |
| 12 | Donald C. Rogness | Vividion Therapeutics (United … (US) | — |
| 13 | Betty Lam | Vividion Therapeutics (United … (US) | — |
| 14 | Maria E. Rodriguez-Aguirre | Vividion Therapeutics (United … (US) | |
| 15 | David R. Woody | Vividion Therapeutics (United … (US) | — |
| 16 | Christie L. Eissler | Vividion Therapeutics (United … (US) | |
| 17 | Socorro Rodiles | Vividion Therapeutics (United … (US) | — |
| 18 | Seth M. Negron | Vividion Therapeutics (United … (US) | — |
| 19 | Steffen M. Bernard | Vividion Therapeutics (United … (US) | |
| 20 | Eileen Tran | Vividion Therapeutics (United … (US) | |
| 21 | Jonathan Pollock | Vividion Therapeutics (United … (US) | |
| 22 | Ali Tabatabaei | Vividion Therapeutics (United … (US) | — |
| 23 | Víctor Contreras | Vividion Therapeutics (United … (US) | |
| 24 | Heather N. Williams | Vividion Therapeutics (United … (US) | |
| 25 | Martha Katherine Pastuszka | Vividion Therapeutics (United … (US) | |
| 26 | John J. Sigler | Vividion Therapeutics (United … (US) | |
| 27 | Markus Georg Rudolph | F. Hoffmann-La Roche AG (CH) | |
| 28 | Moritz Classen | F. Hoffmann-La Roche AG (CH) | — |
| 29 | Doris Brugger | F. Hoffmann-La Roche AG (CH) | — |
| 30 | Christopher F. Claiborne | F. Hoffmann-La Roche AG (CH) | — |
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