Universal Anti-CD7 CAR-T Cells Targeting T-ALL and Functiona…

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2023
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  • DOI 10.1089/hum.2023.029
  • PMID https://pubmed.ncbi.nlm.nih.gov/37861302
  • OpenAlex ID W4387798398
  • Type Article
  • Language EN
  • Published 20 Oct 2023
  • Volume 34 (23-24)
  • Pages 1257–1272
  • Source Human Gene Therapy
  • Publisher Mary Ann Liebert, Inc.
  • FWCI 1.09
  • Countries 1
  • Institutions 3
  • Added 21 Oct 2023
  • Updated 31 Oct 2026
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Universal Anti-CD7 CAR-T Cells Targeting T-ALL and Functional Analysis of CD7 Antigen on T/CAR-T Cells

Article 2023 EN

Chimeric antigen receptor T (CAR-T) cell therapy initiates new methods and turns the scale of clinical treatment on relapsed/refractory acute T lymphoblastic leukemia (T-ALL). In this study, we generated the second-generation CD7-targeting CAR-T cells with a new antigen-binding single-chain variable fragment sequence and made it universal via CRISPR-based knockout of TRAC and CD7 genes (termed UCA…

9

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32

References

13

Authors

1.09

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Authors & Affiliations
13 authors
#AuthorInstitutionsORCID
1 Leling Xie Chinese Academy of Medical Sci… (CN) Institute of Hematology & Bloo… (CN) +1
2 Runxia Gu Chinese Academy of Medical Sci… (CN) Institute of Hematology & Bloo… (CN) +1
3 Xue Yang Chinese Academy of Medical Sci… (CN) Institute of Hematology & Bloo… (CN) +1
4 Shaowei Qiu Chinese Academy of Medical Sci… (CN) Institute of Hematology & Bloo… (CN) +1
5 Yingxi Xu Chinese Academy of Medical Sci… (CN) Institute of Hematology & Bloo… (CN) +1
6 Junli Mou Chinese Academy of Medical Sci… (CN) Institute of Hematology & Bloo… (CN) +1
7 Ying Wang Chinese Academy of Medical Sci… (CN) Institute of Hematology & Bloo… (CN) +1
8 Haiyan Xing Chinese Academy of Medical Sci… (CN) Institute of Hematology & Bloo… (CN) +1
9 Kejing Tang Chinese Academy of Medical Sci… (CN) Institute of Hematology & Bloo… (CN) +1
10 Zheng Tian Chinese Academy of Medical Sci… (CN) Institute of Hematology & Bloo… (CN) +1 —
11 Qing Rao Chinese Academy of Medical Sci… (CN) Institute of Hematology & Bloo… (CN) +1
12 Min Wang Corresponding Chinese Academy of Medical Sci… (CN) Institute of Hematology & Bloo… (CN) +1
13 Jianxiang Wang Corresponding Chinese Academy of Medical Sci… (CN) Institute of Hematology & Bloo… (CN) +1
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