Identification of putative druggable pockets in PRL3, a sign…

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2023
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Work Details
  • DOI 10.1101/2023.07.31.551065
  • OpenAlex ID W4385459348
  • Type Preprint
  • Language EN
  • Published 31 Jul 2023
  • Source bioRxiv (Cold Spring Harbor Laboratory)
  • Publisher Cold Spring Harbor Laboratory
  • Countries 1
  • Institutions 1
  • Added 10 Oct 2025
  • Updated 22 Sep 2026
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Identification of putative druggable pockets in PRL3, a significant oncology target, using in silico analysis

Preprint 2023 EN Green

Abstract Due to their active roles in regulating phosphorylations, protein tyrosine phosphatases (PTP) have emerged as attractive targets in diseases characterized by aberrant phosphorylations such as cancers. The activity of the phosphatase of regenerating liver 3, PRL3, has been linked to several oncogenic and metastatic pathways, particularly in breast, ovarian, colorectal, and blood cancers. D…

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3 authors
#AuthorInstitutionsORCID
1 Grace M. Bennett Georgia Southern University (US)
2 Julia Starczewski Georgia Southern University (US) —
3 Mark Vincent C. dela Cerna Corresponding Georgia Southern University (US)
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