FBXL4 deficiency promotes mitophagy by elevating NIX

Emerging

6
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54
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2022
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Work Details
  • DOI 10.1101/2022.10.11.511735
  • OpenAlex ID W4304632696
  • Type Preprint
  • Language EN
  • Published 11 Oct 2022
  • Source bioRxiv (Cold Spring Harbor Laboratory)
  • Publisher Cold Spring Harbor Laboratory
  • Countries 3
  • Institutions 6
  • Added 12 Oct 2022
  • Updated 12 Oct 2026
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FBXL4 deficiency promotes mitophagy by elevating NIX

Preprint 2022 EN Green

Abstract The selective autophagy of mitochondria is linked to mitochondrial quality control and is critical to a healthy organism. We have conducted a CRISPR/Cas9 screen of human E3 ubiquitin ligases for influence on mitophagy under both basal cell culture conditions and following acute mitochondrial depolarisation. We identify two Cullin RING ligases, VHL and FBXL4 as the most profound negative r…

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UN Sustainable Development Goals
1 SDGs
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8 authors
#AuthorInstitutionsORCID
1 Hannah Elcocks University of Liverpool (GB)
2 Ailbhe Jane Brazel University of Liverpool (GB) National University of Ireland… (IE)
3 Katy R. McCarron University of Liverpool (GB)
4 Manuel Kaulich Goethe University Frankfurt (DE) University Hospital Frankfurt (DE) +1
5 Koraljka Husnjak Frankfurt Cancer Institute (DE)
6 Heather Mortiboys University of Sheffield (GB)
7 Michael J. Clague Corresponding University of Liverpool (GB)
8 Sylvie Urbé Corresponding University of Liverpool (GB)
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