Bardet-Biedl Syndrome 2 (BBS2) Depletion Affects Primary Cilia in Pancreatic Islets and Glucose Homeostasis

Bardet-Biedl Syndrome (BBS) is a pleiotropic ciliopathy characterized by a unique phenotype including obesity and type II diabetes, which has drawn attention to the disease as a way to discover new biochemical and developmental pathways related to the disease’s phenotypic manifestations. BBS2 knockout resulted in low insulin levels, disregulation of glucose homeostasis, and a unique phenotype of a…