Effective chiral pool synthesis of both enantiomers of the T…
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- DOI 10.1002/ardp.202100362
- PMID https://pubmed.ncbi.nlm.nih.gov/34738656
- OpenAlex ID W3210430612
- Type Article
- Language EN
- Published 05 Nov 2021
- Volume 355 (2)
- Pages e2100362
- Source Archiv der Pharmazie
- Publisher Wiley
- FWCI 0.69
- Countries 1
- Institutions 1
- Added 08 Nov 2021
- Updated 28 Oct 2026
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Effective chiral pool synthesis of both enantiomers of the TRPML inhibitor trans‐ML‐SI3
Article 2021 EN Hybrid
Two independent chiral pool syntheses of both enantiomers of the TRPML inhibitor, trans-ML-SI3, were developed, starting from commercially available (1S,2R)- and (1R,2S)-configured cis-2-aminocyclohexanols. Both routes lead to the target compounds in excellent enantiomeric purity and good overall yields. For the most attractive (-)-trans-enantiomer, the R,R-configuration was identified by these un…
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4 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Katharina Kriegler | Ludwig-Maximilians-Universität… (DE) | — |
| 2 | Charlotte Leser | Ludwig-Maximilians-Universität… (DE) | |
| 3 | Péter Mayer | Ludwig-Maximilians-Universität… (DE) | |
| 4 | Franz Bracher Corresponding | Ludwig-Maximilians-Universität… (DE) |
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