Endothelial Nox2 Limits Systemic Inflammation and Hypotensio…
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6
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- DOI 10.1097/shk.0000000000001706
- PMID https://pubmed.ncbi.nlm.nih.gov/34276040
- OpenAlex ID W3115697086
- Type Article
- Language EN
- Published 15 Dec 2020
- Volume 56 (2)
- Pages 268–277
- Source Shock
- Publisher Lippincott Williams & Wilkins
- FWCI 0.26
- Countries 3
- Institutions 5
- Added 05 Jan 2021
- Updated 27 Oct 2026
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Endothelial Nox2 Limits Systemic Inflammation and Hypotension in Endotoxemia by Controlling Expression of Toll-Like Receptor 4
Article 2020 EN Hybrid
ABSTRACT: Leukocyte Nox2 is recognized to have a fundamental microbicidal function in sepsis but the specific role of Nox2 in endothelial cells (EC) remains poorly elucidated. Here, we tested the hypothesis that endothelial Nox2 participates in the pathogenesis of systemic inflammation and hypotension induced by LPS. LPS was injected intravenously in mice with Tie2-targeted deficiency or transgeni…
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15
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0.26
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1 SDGsAuthors & Affiliations
15 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Silvia Cellone Trevelin Corresponding | King's College London (GB) British Heart Foundation (GB) | |
| 2 | Can Martin Sag | University Hospital Regensburg (DE) | |
| 3 | Min Zhang Corresponding | King's College London (GB) British Heart Foundation (GB) | |
| 4 | José Carlos Alves-Filho | Universidade de São Paulo (BR) | |
| 5 | Thiago M. Cunha | Universidade de São Paulo (BR) | |
| 6 | Célio Xavier dos Santos Corresponding | King's College London (GB) British Heart Foundation (GB) | — |
| 7 | Greta Jane Sawyer Corresponding | King's College London (GB) British Heart Foundation (GB) | |
| 8 | Thomas V. Murray Corresponding | King's College London (GB) British Heart Foundation (GB) | |
| 9 | Alison C. Brewer Corresponding | King's College London (GB) British Heart Foundation (GB) | |
| 10 | Francisco Rafael Martins Laurindo | Instituto do Coração - HCFMUSP (BR) | |
| 11 | Andrea Protti Corresponding | King's College London (GB) British Heart Foundation (GB) | |
| 12 | Lucia Rossetti Lopes | Universidade de São Paulo (BR) | |
| 13 | Aleksandar Ívetic Corresponding | King's College London (GB) British Heart Foundation (GB) | |
| 14 | Fernando Q. Cunha | Universidade de São Paulo (BR) | |
| 15 | Ajay M. Shah Corresponding | King's College London (GB) British Heart Foundation (GB) |
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