CLAZAKIZUMAB (ANTI-IL-6) INDUCES FOXP3+ TREGS IN HIGHLY HLA …

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  • DOI 10.1097/01.tp.0000698800.17823.68
  • OpenAlex ID W3082683361
  • Type Conference-abstract
  • Language EN
  • Published 28 Aug 2020
  • Volume 104 (S3)
  • Pages S105
  • Source Transplantation
  • Publisher Wolters Kluwer
  • Countries 1
  • Institutions 1
  • Added 08 Sep 2020
  • Updated 01 Oct 2026
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CLAZAKIZUMAB (ANTI-IL-6) INDUCES FOXP3+ TREGS IN HIGHLY HLA SENSITIZED PATIENTS RECEIVING HLAI KIDNEY TRANSPLANTATION (NCT03380962)

Conference-abstract 2020 EN

Introduction: Interleukin-6 is an important inflammatory cytokine which also acts as a growth factor for B-cells, plasma cells and Th17 cells. IL-6 also inhibits FoxP3+ Treg cells. These considerations suggest blocking IL-6 may be an important method to reduce inflammation and Th17 mediated injury in kidney allografts. Patients & Methods: Clazakizumab (Vitaeris Inc.) is a humanized monoclonal anti…

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13 authors
#AuthorInstitutionsORCID
1 Stanley C. Jordan Cedars-Sinai Medical Center (US)
2 Shili Ge Cedars-Sinai Medical Center (US) —
3 Nori Ammerman Cedars-Sinai Medical Center (US) —
4 Mieko Toyoda Cedars-Sinai Medical Center (US)
5 Edmund Huang Cedars-Sinai Medical Center (US)
6 Alice Peng Cedars-Sinai Medical Center (US)
7 Reiad Najjar Cedars-Sinai Medical Center (US)
8 Supreet Sethi Cedars-Sinai Medical Center (US)
9 Summer Williamson Cedars-Sinai Medical Center (US) —
10 Kate Myers Cedars-Sinai Medical Center (US) —
11 Kathlyn Lim Cedars-Sinai Medical Center (US)
12 Jua Choi Cedars-Sinai Medical Center (US)
13 Ashley A. Vo Cedars-Sinai Medical Center (US)
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