Small Trafficking Inhibitor Retro-2 Disrupts the Microtubule…

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DOI 10.3389/fcell.2020.00464
PMID https://pubmed.ncbi.nlm.nih.gov/32626708
PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/7314991
OpenAlex ID W3036214510
Type Article
Language EN
Published 18 Jun 2020
Volume 8
Pages 464
Source Frontiers in Cell and Developmental Biol…
Publisher Frontiers Media
FWCI 0.72
Countries 1
Institutions 4
Added 25 Jun 2020
Updated 28 Oct 2026

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Small Trafficking Inhibitor Retro-2 Disrupts the Microtubule-Dependent Trafficking of Autophagic Vacuoles

Article 2020 EN Gold

Autophagy is a catabolic recycling process by which a cell degrades its own constituents to contribute to cell homeostasis or survival. We report that the small trafficking inhibitor Retro-2 impairs microtubule-dependent vacuolar trafficking in autophagy. Retro-2 induced autophagy and promoted the dramatic cytoplasmic accumulation of large autophagosomes. Moreover, Retro-2 decreased the spreading…

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0.72

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UN Sustainable Development Goals

1 SDGs

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2 authors

#	Author	Institutions	ORCID
1	Valérie Nicolas	Université Paris-Saclay (FR) Ingénierie et Plateformes au S… (FR)
2	Vanessa Liévin-Le Moal Corresponding	Inserm (FR) Inflammation, Microbiome and I… (FR)

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