Role of Chromatograph-based Analytical Techniques in Quantification of Chiral Compounds: An Update

Background: Chiral purity is a critical quality attribute of pharmaceutical materials as chiral compounds are known to exhibit different pharmacological and toxicological properties as compared to those of their enantiomers (or diastereomers for molecules with multiple chiral centers). It is important to note that about 40% of the synthetic drugs are chiral, 60% of all pharmaceuticals are chiral a…