Impact of the Protein Data Bank on antineoplastic approvals
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- DOI 10.1016/j.drudis.2020.02.002
- PMID https://pubmed.ncbi.nlm.nih.gov/32068073
- OpenAlex ID W3006549693
- Type Article
- Language EN
- Published 14 Feb 2020
- Volume 25 (5)
- Pages 837–850
- Source Drug Discovery Today
- Publisher Elsevier BV
- FWCI 2.95
- Countries 1
- Institutions 4
- Added 10 Oct 2025
- Updated 16 Oct 2026
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Impact of the Protein Data Bank on antineoplastic approvals
Article 2020 EN Hybrid
Open access to 3D structure information from the Protein Data Bank (PDB) facilitated discovery and development of >90% of the 79 new antineoplastic agents (54 small molecules, 25 biologics) with known molecular targets approved by the FDA 2010-2018. Analyses of PDB holdings, the scientific literature and related documents for each drug-target combination revealed that the impact of public-domain 3…
31
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145
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4
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2.95
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1 SDGsAuthors & Affiliations
4 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | John Westbrook | Rutgers, The State University … (US) | |
| 2 | Rose Soskind | Rutgers, The State University … (US) | |
| 3 | Brian P. Hudson | Rutgers, The State University … (US) | |
| 4 | Stephen Kevin Burley Corresponding | Rutgers, The State University … (US) San Diego Supercomputer Center (US) +2 |
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