A potent antiarrhythmic drug N-methyl berbamine extends the …
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- DOI 10.1016/j.jphs.2019.12.008
- PMID https://pubmed.ncbi.nlm.nih.gov/31992491
- OpenAlex ID W2998043135
- Type Article
- Language EN
- Published 31 Dec 2019
- Volume 142 (4)
- Pages 131–139
- Source Journal of Pharmacological Sciences
- Publisher Elsevier BV
- FWCI 1.28
- Countries 1
- Institutions 2
- Added 10 Jan 2020
- Updated 24 Oct 2026
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A potent antiarrhythmic drug N-methyl berbamine extends the action potential through inhibiting both calcium and potassium currents
Article 2019 EN Gold
N-methyl berbamine (N-MB) is a berberine derivative. Its analogue berbamine has been reported to have remarkable antiarrhythmic and ischemic protective effects. However, the pharmacological effects of N-MB are ill-defined. In this study, molecular docking was used to evaluate the binding of N-MB to CaV1.2 Ca2+ and KV11.1 K+ channels, and the effects of N-MB on action potential and ionic currents w…
45
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33
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10
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1.28
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1 SDGsAuthors & Affiliations
10 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Huiyuan Hu | China Medical University (CN) | |
| 2 | Shi Zhou | China Medical University (CN) | |
| 3 | Xiaodong Sun | China Medical University (CN) | |
| 4 | Yingchun Xue | China Medical University (CN) | |
| 5 | Ling Yan | China Medical University (CN) | |
| 6 | Xuanxuan Sun | China Medical University (CN) | — |
| 7 | Ming Lei | Southwest Medical University (CN) | |
| 8 | Jinming Li | China Medical University (CN) | |
| 9 | Xiaorong Zeng Corresponding | Southwest Medical University (CN) | |
| 10 | Liying Hao Corresponding | China Medical University (CN) |
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