CD7 CAR for the Treatment of Acute Myeloid and Lymphoid Leuk…
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- DOI 10.1182/blood.v128.22.4555.4555
- OpenAlex ID W2979737548
- Type Article
- Language EN
- Published 02 Dec 2016
- Volume 128 (22)
- Pages 4555
- Source Blood
- Publisher Elsevier BV
- FWCI 1.26
- Countries 1
- Institutions 3
- Added 18 Oct 2019
- Updated 21 Aug 2026
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CD7 CAR for the Treatment of Acute Myeloid and Lymphoid Leukemia
Article 2016 EN
Abstract CD7 is a T- and NK-cell marker highly expressed in T cell leukemia and in 30% of AML cases, where its presence correlates with chemoresistance and worse prognosis. We created CD7-directed chimeric antigen receptors (CARs) using single chain variable fragment (scFv) sequences derived from three different CD7-specific mAb clones and evaluated the feasibility and potency of using CD7 CAR T c…
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1 SDGsAuthors & Affiliations
5 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | D. Silva | Houston Methodist (US) Baylor College of Medicine (US) +1 | |
| 2 | Haruko Tashiro | Houston Methodist (US) Baylor College of Medicine (US) +1 | |
| 3 | Madhuwanti Srinivasan | Houston Methodist (US) Baylor College of Medicine (US) +1 | — |
| 4 | Malcolm K. Brenner | Houston Methodist (US) Baylor College of Medicine (US) +1 | |
| 5 | Maksim Mamonkin | Houston Methodist (US) Baylor College of Medicine (US) +1 |
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