Proteome-scale discovery of protein interactions with residu…
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- DOI 10.1101/791293
- OpenAlex ID W2977939402
- Type Preprint
- Language EN
- Published 02 Oct 2019
- Source bioRxiv (Cold Spring Harbor Laboratory)
- Publisher Cold Spring Harbor Laboratory
- Countries 2
- Institutions 6
- Added 10 Oct 2025
- Updated 14 Oct 2026
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Proteome-scale discovery of protein interactions with residue-level resolution using sequence coevolution
Preprint 2019 EN Green
Abstract The majority of protein interactions in most organisms are unknown, and experimental methods for determining protein interactions can yield divergent results. Here we use an orthogonal, purely computational method based on sequence coevolution to discover protein interactions at large scale. In the model organism Escherichia coli , 53% of protein pairs in the proteome are eligible for our…
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6 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Anna G. Green | Harvard University (US) | |
| 2 | Hadeer Elhabashy | Max Planck Institute for Devel… (DE) University of Tübingen (DE) | |
| 3 | Kelly P. Brock | Harvard University (US) | |
| 4 | Rohan Maddamsetti | Harvard University (US) | |
| 5 | Oliver Kohlbacher Corresponding | Universitätsklinikum Tübingen (DE) Max Planck Institute for Devel… (DE) +2 | |
| 6 | Debora S. Marks Corresponding | Broad Institute (US) Harvard University (US) |
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