Platelets regulate innate immunity in autoinflammatory diseases and cancer

The interleukin (IL)-1 family of pro-inflammatory cytokines are the most potent pyrogens in the body, and their excessive production can cause several auto- inflammatory syndromes, or contribute to a range of inflammatory and metabolic disorders. Furthermore, IL-1β is an important driver of tumor development and metastasis. The recent success of the first and largest randomized trial of the therap…