Two isoforms of cyclic GMP-dependent kinase-I exhibit distin…

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Two isoforms of cyclic GMP-dependent kinase-I exhibit distinct expression patterns in the adult mouse dorsal root ganglion

Article 2018 EN Gold

cGMP-dependent kinase-I (cGKI) is known to regulate spinal pain processing. This enzyme consists of two isoforms (cGKIα and cGKIβ) that show distinct substrate specificity and tissue distribution. It has long been believed that the α isoform is exclusively expressed in the adult dorsal root ganglion. The aim of the present study was to reexamine the expression of cGKI isoforms in the adult mouse d…

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6 authors
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1 Hitoshi Uchida Kansai Medical University (JP) Brain Research Institute, Niig… (JP) +1 —
2 Shinji Matsumura Kansai Medical University (JP)
3 Tayo Katano Kansai Medical University (JP)
4 Masahiko Watanabe Hokkaido University (JP)
5 Jens Schlossmann University of Regensburg (DE)
6 Seiji Ito Corresponding Kansai Medical University (JP)

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