Lipid Nanoparticle-Delivered Chemically Modified mRNA Restor…
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- DOI 10.1016/j.ymthe.2018.05.014
- PMID https://pubmed.ncbi.nlm.nih.gov/29910178
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/6094356
- OpenAlex ID W2808558611
- Type Article
- Language EN
- Published 15 Jun 2018
- Volume 26 (8)
- Pages 2034–2046
- Source Molecular Therapy
- Publisher Elsevier BV
- FWCI 7.02
- Countries 1
- Institutions 2
- Added 21 Jun 2018
- Updated 31 Oct 2026
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Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis
Article 2018 EN Hybrid
The promise of gene therapy for the treatment of cystic fibrosis has yet to be fully clinically realized despite years of effort toward correcting the underlying genetic defect in the cystic fibrosis transmembrane conductance regulator (CFTR). mRNA therapy via nanoparticle delivery represents a powerful technology for the transfer of genetic material to cells with large, widespread populations, su…
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7 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Ema Robinson | Oregon State University (US) | — |
| 2 | Kelvin D. MacDonald | Oregon State University (US) Oregon Health & Science Univer… (US) | |
| 3 | Kai Slaughter | Oregon State University (US) | — |
| 4 | Madison McKinney | Oregon State University (US) | — |
| 5 | Siddharth Patel | Oregon State University (US) | |
| 6 | Conroy Sun | Oregon State University (US) Oregon Health & Science Univer… (US) | |
| 7 | Gaurav Sahay Corresponding | Oregon State University (US) Oregon Health & Science Univer… (US) |
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