Phospholipase D inhibitors reduce human prostate cancer cell…
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- DOI 10.1038/bjc.2017.391
- PMID https://pubmed.ncbi.nlm.nih.gov/29136407
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/5785744
- OpenAlex ID W2768734659
- Type Article
- Language EN
- Published 14 Nov 2017
- Volume 118 (2)
- Pages 189–199
- Source British Journal of Cancer
- Publisher Springer Nature
- FWCI 1.65
- Countries 1
- Institutions 3
- Added 04 Dec 2017
- Updated 28 Oct 2026
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Phospholipase D inhibitors reduce human prostate cancer cell proliferation and colony formation
Article 2017 EN Hybrid
BACKGROUND: Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt. PLD expression and/or activity is raised in breast, colorectal, gastric, kidney and thyroid carcinomas but its role in prostate cancer (PCa), the major cancer of men in t…
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79
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4
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1.65
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1 SDGsAuthors & Affiliations
4 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Amanda R. Noble Corresponding | University of York (GB) | |
| 2 | Norman J. Maitland | University of York (GB) | |
| 3 | Daniel Maurice Berney | Queen Mary University of Londo… (GB) Barts Cancer Institute (GB) | |
| 4 | Martin G. Rumsby | University of York (GB) | — |
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