Differential Ligand Binding Specificities of the Pulmonary C…
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- DOI 10.1021/acs.biochem.6b01313
- PMID https://pubmed.ncbi.nlm.nih.gov/28719181
- OpenAlex ID W2736364978
- Type Article
- Language EN
- Published 18 Jul 2017
- Volume 56 (31)
- Pages 4095–4105
- Source Biochemistry
- Publisher American Chemical Society
- FWCI 0.42
- Countries 1
- Institutions 2
- Added 10 Oct 2025
- Updated 16 Oct 2026
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Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop
Article 2017 EN
Lung surfactant proteins (SPs) play critical roles in surfactant function and innate immunity. SP-A and SP-D, members of the collectin family of C-type lectins, exhibit distinct ligand specificities, effects on surfactant structure, and host defense functions despite extensive structural homology. SP-A binds to dipalmitoylphosphatidylcholine (DPPC), the major surfactant lipid component, but not ph…
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7 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Michael J. Rynkiewicz | Boston University (US) | |
| 2 | Huixing Wu | University of Cincinnati (US) | — |
| 3 | Tanya M. Cafarella | Boston University (US) | — |
| 4 | Nikolaos M. Nikolaidis | University of Cincinnati (US) | |
| 5 | J. W. Head | Boston University (US) | |
| 6 | Barbara A. Seaton | Boston University (US) | |
| 7 | Francis X. McCormack Corresponding | University of Cincinnati (US) |
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