Combined Molecular Modeling Studies of Hsp90 Chaperone Inhibitors by Pharmacophore Model;Molecular Docking and 3D-QSAR

Inhibition of the protein chaperone Hsp90 is a promising approach to cancer therapy.A combined molecular modeling study include pharmacophore modeling,molecular docking and 3D-QSAR were performed to investigate a series of pyrazole-/isoxazole-scaffold inhibitors of human Hsp90α.The best pharmacop...