Exploring the roles of NADPH oxidase (NOX) isoforms, NOX1 and NOX4 in the accelerated development and progression of atherosclerosis in diabetes.

Chronic hyperglycaemia and oxidative stress in diabetes trigger sustained vascular inflammation as well as pronounced aberrations in cellular structure and function, which drive atherosclerosis A major source of reactive oxygen species (ROS) in the vasculature are NADPH Oxidase (NOX) enzymes. The roles of different NOX isoforms, namely NOX1 and NOX4, in immune and vascular cell pathophysiology rem…