Local Inhibition of Complement Improves Mesenchymal Stem Cel…
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- DOI 10.1038/mt.2016.142
- PMID https://pubmed.ncbi.nlm.nih.gov/27377042
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/5113108
- OpenAlex ID W2464515224
- Type Article
- Language EN
- Published 05 Jul 2016
- Volume 24 (9)
- Pages 1665–1674
- Source Molecular Therapy
- Publisher Elsevier BV
- FWCI 2.18
- Countries 1
- Institutions 1
- Added 22 Jul 2016
- Updated 28 Oct 2026
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Local Inhibition of Complement Improves Mesenchymal Stem Cell Viability and Function After Administration
Article 2016 EN Hybrid
The results of recent clinical trials using mesenchymal stem cells (MSCs) have been unsatisfactory, indicating that current MSC-based therapies need to be improved. We and others have previously demonstrated that MSCs activate complement by unknown mechanisms after infusion, leading to damaged MSCs. In the study reported here, we found that incorporation of N-glycolylneuraminic acid onto MSCs duri…
47
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28
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3
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2.18
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1 SDGsAuthors & Affiliations
3 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Yan Li | Cleveland Clinic (US) | |
| 2 | John J. Fung | Cleveland Clinic (US) | |
| 3 | Feng Lin Corresponding | Cleveland Clinic (US) |
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