ROS-mediated autophagy and its role in the pathogenesis

Reactive oxygen species(ROS) are generally small,short-lived and highly reactive molecules,and formed by incomplete one-electron reduction of oxygen.ROS act as signaling molecules involving in a variety of intracellular processes,such as proliferation,immunity and apoptosis.The intracellular excessive accumulation of ROS may cause oxidative stress,and eventually lead to cell death and to participa…