Preparation of L-Isoleucine-Type Polymer-bonded Chiral Ligand Exchange Stationary Phase and Enantiomeric Separation of DL-Amino Acids

A new stationary phase was synthesized for chiral-ligand-exchange chromatography from a reaction of L-isoleucine with monodispersed poly(glycidylmethacrylate-co-ethylenedimethacrylate) particles.The enantiomeric resolutions of 12 DL-amino acids were achieved on the synthesized chiral ligand exchange chromatographic stationary phase with 0.2 mol/L NaAc and 0.1 mmol/L Cu(Ac)2 aqueous solution as mob…