Phorbol Ester-Induced LH Release in Pituitary Gonadotrophs: …

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1991
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Phorbol Ester-Induced LH Release in Pituitary Gonadotrophs: Effects of Antagonists of Calmodulin and GnRH.

Article 1991 EN Bronze

The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent activator of Ca(2+)- and phospholipid-dependent protein kinase (C kinase), stimulates luteinizing hormone (LH) release from rat pituitary cells. The actions of TPA upon LH release were compared with those of the GnRH superagonist [D-Ala6] des-Gly10-GnRH N-ethylamide (GnRHa) in cultured pituitary cells. LH release was stimulate…

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7 authors
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1 Shun‐ichiro Izumi Keio University (JP)
2 Mitsutoshi Iwashita —
3 Tsunehisa Makino Keio University (JP) —
4 Suguru Saito Keio University (JP)
5 Shoichi Sakamoto —
6 Yoshihiko Takeda Tokyo Women's Medical Universi… (JP)
7 Shiro Nozawa Keio University (JP) —

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