Mutations flanking the carbohydrate binding site of surfacta…
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- DOI 10.1152/ajplung.00035.2014
- PMID https://pubmed.ncbi.nlm.nih.gov/24705721
- OpenAlex ID W2332762308
- Type Article
- Language EN
- Published 05 Apr 2014
- Volume 306 (11)
- Pages L1036–L1044
- Source American Journal of Physiology-Lung Cell…
- Publisher American Physical Society
- FWCI 1.01
- Countries 1
- Institutions 4
- Added 24 Jun 2016
- Updated 27 Oct 2026
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Mutations flanking the carbohydrate binding site of surfactant protein D confer antiviral activity for pandemic influenza A viruses
Article 2014 EN Green
We recently reported that a trimeric neck and carbohydrate recognition domain (NCRD) fragment of human surfactant protein D (SP-D), a host defense lectin, with combinatorial substitutions at the 325 and 343 positions (D325A+R343V) exhibits markedly increased antiviral activity for seasonal strains of influenza A virus (IAV). The NCRD binds to glycan-rich viral envelope proteins including hemagglut…
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11 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Nikolaos M. Nikolaidis | University of Cincinnati (US) | |
| 2 | Mitchell R. White | Boston University (US) | |
| 3 | Kimberly Allen | Washington University in St. L… (US) | — |
| 4 | Shweta Tripathi | Boston University (US) | |
| 5 | Li Qi | National Institute of Allergy … (US) | |
| 6 | Barbara McDonald | Washington University in St. L… (US) | — |
| 7 | Jeffery K. Taubenberger | National Institute of Allergy … (US) | |
| 8 | Barbara A. Seaton | Boston University (US) | |
| 9 | Francis X. McCormack | University of Cincinnati (US) | |
| 10 | Erika C. Crouch | Washington University in St. L… (US) | — |
| 11 | Kevan L. Hartshorn Corresponding | Boston University (US) |
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