Interaction of tumor cells with infiltrating lymphocytes via…

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DOI 10.1080/2162402x.2015.1049805
PMID https://pubmed.ncbi.nlm.nih.gov/26587319
PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/4635726
OpenAlex ID W2185985010
Type Article
Language EN
Published 29 May 2015
Volume 4 (12)
Pages e1049805
Source OncoImmunology
Publisher Landes Bioscience
FWCI 0.58
Countries 1
Institutions 1
Added 24 Jun 2016
Updated 28 Oct 2026

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Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma

Article 2015 EN Gold

CD70 upregulation by hypoxia-inducible factor and CD27+ lymphocyte tumor infiltration are associated with worse survival in von Hippel-Lindau gene (VHL) mutated clear cell renal cell carcinoma (ccRCC). CD70/CD27 interaction is accompanied by high soluble CD27 levels in the sera of ccRCC patients suggesting that soluble CD27 is a potential predictive tool for anti-CD70 therapy.

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3

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0.58

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UN Sustainable Development Goals

1 SDGs

Authors & Affiliations

3 authors

#	Author	Institutions	ORCID
1	Melanie Ruf Corresponding	University Hospital Zurich (CH)	—
2	Holger Moch	University Hospital Zurich (CH)
3	Peter Schraml	University Hospital Zurich (CH)

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