Effects of dose and duration of treatment with the tumor-pro…

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Effects of dose and duration of treatment with the tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate on mouse skin carcinogenesis

Article 1980 EN

The effects of dose and duration of treatment with the potent tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) on the formation of skin tumors in Charles River CD-1 mice was studied. Mice were initiated with a single application of 0.2 micromol of 7,12-dimethylbenz[a]anthracene (DMBA) in 0.2 ml acetone. Beginning two weeks after initiation, mice were treated twice weekly with vario…

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1 Ajit Kumar Verma University of Wisconsin–Madiso… (US)
2 Roswell K. Boutwell University of Wisconsin–Madiso… (US) —

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