A designed protein as experimental model of primordial foldi…

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  • DOI 10.1073/pnas.0812108106
  • PMID https://pubmed.ncbi.nlm.nih.gov/19240216
  • OpenAlex ID W2150032734
  • Type Article
  • Language EN
  • Published 24 Feb 2009
  • Volume 106 (11)
  • Pages 4127–4132
  • Source Proceedings of the National Academy of S…
  • Publisher National Academy of Sciences
  • FWCI 2.16
  • Countries 2
  • Institutions 4
  • Added 10 Oct 2025
  • Updated 10 Oct 2026
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A designed protein as experimental model of primordial folding

Article 2009 EN Green

How do proteins accomplish folding during early evolution? Theoretically the mechanism involves the selective stabilization of the native structure against all other competing compact conformations in a process that involves cumulative changes in the amino acid sequence along geological timescales. Thus, an evolved protein folds into a single structure at physiological temperature, but the conform…

34

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5

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2.16

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1 Mourad Sadqi Consejo Superior de Investigac… (ES) Centro de Investigaciones Biol… (ES) +1
2 Eva de Alba University of Maryland, Colleg… (US)
3 Raúl Pérez‐Jiménez Consejo Superior de Investigac… (ES) Universidad de Granada (ES) +1
4 José M. Sánchez‐Ruiz Universidad de Granada (ES)
5 Víctor Muñoz Consejo Superior de Investigac… (ES) Centro de Investigaciones Biol… (ES) +1
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