Refined Geographic Distribution of the Oriental ALDH2*504Lys…
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- DOI 10.1111/j.1469-1809.2009.00517.x
- PMID https://pubmed.ncbi.nlm.nih.gov/19456322
- OpenAlex ID W2149623954
- Type Article
- Language EN
- Published 28 Apr 2009
- Volume 73 (3)
- Pages 335–345
- Source Annals of Human Genetics
- Publisher Wiley
- FWCI 5.25
- Countries 7
- Institutions 14
- Added 24 Jun 2016
- Updated 24 Oct 2026
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Refined Geographic Distribution of the Oriental ALDH2*504Lys (nee 487Lys) Variant
Article 2009 EN Green
Mitochondrial aldehyde dehydrogenase (ALDH2) is one of the most important enzymes in human alcohol metabolism. The oriental ALDH2*504Lys variant functions as a dominant negative, greatly reducing activity in heterozygotes and abolishing activity in homozygotes. This allele is associated with serious disorders such as alcohol liver disease, late onset Alzheimer disease, colorectal cancer, and esoph…
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1 SDGsAuthors & Affiliations
18 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Hui Li | Fudan University (CN) Yale University (US) +1 | |
| 2 | S. A. Borinskaya | Russian Academy of Sciences (RU) Vavilov Institute of General G… (RU) | |
| 3 | Kimio Yoshimura Corresponding | Keio University (JP) National Cancer Center Researc… (JP) +1 | — |
| 4 | N. R. Kal’ina | Russian Academy of Sciences (RU) Vavilov Institute of General G… (RU) | — |
| 5 | Andrey V. Marusin | Research Institute of Medical … (RU) | |
| 6 | В. А. Степанов | Research Institute of Medical … (RU) | |
| 7 | Zhendong Qin | Fudan University (CN) State Key Laboratory of Geneti… | — |
| 8 | Shagufta Khaliq | Sindh Institute of Urology and… (PK) | |
| 9 | Mi‐Young Lee Corresponding | Keio University (JP) Yale University (US) +1 | — |
| 10 | Yajun Yang | Fudan University (CN) State Key Laboratory of Geneti… | |
| 11 | Aisha Mohyuddin | Shifa Tameer-e-Millat Universi… (PK) | — |
| 12 | David Gurwitz | Tel Aviv University (IL) | |
| 13 | Syed Qasim Mehdi | Sindh Institute of Urology and… (PK) | — |
| 14 | Evgeny Ivanovich Rogaev | Russian Academy of Sciences (RU) University of Massachusetts Ch… (US) +2 | |
| 15 | Jin Li | Fudan University (CN) State Key Laboratory of Geneti… | |
| 16 | Nick K. Yankovsky | Russian Academy of Sciences (RU) Vavilov Institute of General G… (RU) | |
| 17 | Kenneth K. Kídd | Yale University (US) | |
| 18 | Kenneth K. Kídd Corresponding | Keio University (JP) Yale University (US) +1 |
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