Loss of Nfkb1 leads to early onset aging
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- DOI 10.18632/aging.100702
- PMID https://pubmed.ncbi.nlm.nih.gov/25553648
- PMCID https://www.ncbi.nlm.nih.gov/pmc/articles/4276787
- OpenAlex ID W2130156384
- Type Article
- Language EN
- Published 01 Dec 2014
- Volume 6 (11)
- Pages 931–942
- Source Aging
- Publisher Impact Journals LLC
- FWCI 2.83
- Countries 1
- Institutions 1
- Added 24 Jun 2016
- Updated 28 Oct 2026
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Loss of Nfkb1 leads to early onset aging
Article 2014 EN Hybrid
NF-κB is a major regulator of age-dependent gene expression and the p50/NF-κB1 subunit is an integral modulator of NF-κB signaling. Here, we examined Nfkb1-/- mice to investigate the relationship between this subunit and aging. Although Nfkb1-/- mice appear similar to littermates at six months of age, by 12 months they have a higher incidence of several observable age-related phenotypes. In additi…
97
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52
References
9
Authors
2.83
FWCI
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
9 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Giovanna M. Bernal | University of Chicago (US) | — |
| 2 | Joshua S. Wahlstrom | University of Chicago (US) | — |
| 3 | Clayton D. Crawley | University of Chicago (US) | — |
| 4 | Kirk E. Cahill | University of Chicago (US) | |
| 5 | Peter Pytel | University of Chicago (US) | |
| 6 | Hua Laura Liang | University of Chicago (US) | |
| 7 | Shijun Kang | University of Chicago (US) | — |
| 8 | Ralph R. Weichselbaum | University of Chicago (US) | |
| 9 | Bakhtiar Yamini Corresponding | University of Chicago (US) |
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