Effect of Neutralizing Sera on Factor X-Mediated Adenovirus …

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76
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30
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2008
Year
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  • DOI 10.1128/jvi.01878-08
  • PMID https://pubmed.ncbi.nlm.nih.gov/18945780
  • OpenAlex ID W2108399086
  • Type Article
  • Language EN
  • Published 22 Oct 2008
  • Volume 83 (1)
  • Pages 479–483
  • Source Journal of Virology
  • Publisher American Society for Microbiology
  • FWCI 2.65
  • Countries 2
  • Institutions 8
  • Added 24 Jun 2016
  • Updated 27 Oct 2026
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Effect of Neutralizing Sera on Factor X-Mediated Adenovirus Serotype 5 Gene Transfer

Article 2008 EN Green

The deployment of adenovirus serotype 5 (Ad5)-based vectors is hampered by preexisting immunity. When such vectors are delivered intravenously, hepatocyte transduction is mediated by the hexon-coagulation factor X (FX) interaction. Here, we demonstrate that human sera efficiently block FX-mediated cellular binding and transduction of Ad5-based vectors in vitro. Neutralizing activity correlated wel…

76

Citations

30

References

10

Authors

2.65

FWCI

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UN Sustainable Development Goals
1 SDGs
Authors & Affiliations
10 authors
#AuthorInstitutionsORCID
1 Alan L. Parker British Heart Foundation (GB) University of Glasgow (GB)
2 Simon N. Waddington The Royal Free Hospital (GB) University College London (GB)
3 Suzanne M. K. Buckley The Royal Free Hospital (GB) University College London (GB)
4 Jerome H. H. V. Custers Johnson & Johnson (Netherlands… (NL)
5 Menzo J E Havenga Netherlands Organisation for A… (NL)
6 Nico van Rooijen Amsterdam UMC Location Vrije U… (NL)
7 Jaap Goudsmit Johnson & Johnson (Netherlands… (NL) —
8 John H. McVey Thrombosis Research Institute (GB)
9 Stuart A. Nicklin British Heart Foundation (GB) University of Glasgow (GB)
10 Andrew Howard Baker Corresponding British Heart Foundation (GB) University of Glasgow (GB)
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