Cytochrome P450 Reductase: A Harbinger of Diffusible Reduced…
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- DOI 10.1371/journal.pone.0013272
- PMID https://pubmed.ncbi.nlm.nih.gov/20967245
- OpenAlex ID W2092878622
- Type Article
- Language EN
- Published 13 Oct 2010
- Volume 5 (10)
- Pages e13272
- Source PLoS ONE
- Publisher Public Library of Science
- FWCI 0.98
- Countries 1
- Institutions 1
- Added 24 Jun 2016
- Updated 27 Oct 2026
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Cytochrome P450 Reductase: A Harbinger of Diffusible Reduced Oxygen Species
Article 2010 EN Gold
The bi-enzymatic system of cytochrome P450 (CYP, a hemoprotein) and cytochrome P450 reductase (CPR, a diflavoenzyme) mediate the redox metabolism of diverse indigenous and xenobiotic molecules in various cellular and organ systems, using oxygen and NADPH. Curiously, when a 1:1 ratio is seen to be optimal for metabolism, the ubiquitous CYP:CPR distribution ratio is 10 to 100:1 or higher. Further, t…
53
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3 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Kelath Murali Manoj Corresponding | Vellore Institute of Technolog… (IN) | |
| 2 | Sudeep Kumar Gade | Vellore Institute of Technolog… (IN) | — |
| 3 | Lazar Mathew | Vellore Institute of Technolog… (IN) | — |
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