Enterochromaffin-like Cells in Rat Stomach Respond to Short-Term Infusion of High Doses of Cholecystokinin But Not to Long-Term, Sustained, Moderate HyperCCKemia Caused by Continuous Cholecystokinin Infusion or Pancreaticobiliary Diversion

The histamine-producing enterochromaffin-like (ECL) cells in the oxyntic mucosa are controlled by gastrin. An acute gastrin challenge induces release and accelerated resynthesis of ECL cell histamine. Long-term stimulation with gastrin causes ECL cell hyperplasia. We set out to study whether the ECL cells respond not only to gastrin but also to cholecystokinin (CCK). A wide dose range of gastrin-1…