Pronociceptive effects of a TRPA1 channel agonist methylglyo…
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- DOI 10.1016/j.sjpain.2013.07.016
- OpenAlex ID W2020010140
- Type Article
- Language EN
- Published 01 Oct 2013
- Volume 4 (4)
- Pages 260
- Source Scandinavian Journal of Pain
- Publisher Elsevier BV
- Countries 1
- Institutions 2
- Added 10 Oct 2025
- Updated 21 Aug 2026
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Pronociceptive effects of a TRPA1 channel agonist methylglyoxal in healthy control and diabetic animals
Article 2013 EN
Abstract Aims Methylglyoxal (MG), a reactive carbonyl compound generated in diabetes mellitus (DM), activates the TRPA1 ion channel. Here we studied whether MG induces mechanical hypersensitivity or ongoing pain and whether the pronociceptive effect of MG is changed following its sustained endogenous release in DM. Methods DM was induced by streptozotocin (50-60 mg/kg i.p.) in the rat. MG and Chem…
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UN Sustainable Development Goals
1 SDGsAuthors & Affiliations
6 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Hanna Viisanen | University of Helsinki (FI) | |
| 2 | Maria Lasierra | University of Helsinki (FI) | — |
| 3 | Hong Wei | University of Helsinki (FI) | |
| 4 | Ari Koivisto | Orion Corporation (Finland) (FI) | |
| 5 | Karl E.O. Åkerman | University of Helsinki (FI) | |
| 6 | Antti Pertovaara | University of Helsinki (FI) |
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