Synthesis of nucleoside analogs from hydrazine derivatives

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1978
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  • DOI 10.1093/nar/1.suppl_2.s251
  • OpenAlex ID W2017332698
  • Type Article
  • Language EN
  • Published 01 Jul 1978
  • Volume 5 (suppl_2)
  • Pages s251–s256
  • Source Nucleic Acids Research
  • Publisher Oxford University Press
  • FWCI 0.59
  • Countries 1
  • Institutions 1
  • Added 24 Jun 2016
  • Updated 27 Oct 2026
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Synthesis of nucleoside analogs from hydrazine derivatives

Article 1978 EN Green

Reaction of 6-hydrazino-l,3-dimethyluracil (1) with glycosyl isothiocyanates (2a,b,c) gave the glycosyl thiosemicarbazides (3a,b,c) in good yield, which were cyclized to pyrimidothiadiazines (5a,b,c) with NBS oxidation. And 5a,b,c were converted to pyrazolopyrimidines (6a,b,c) by thermal desulfurization. Reaction of aldoses (7a-d), ketoses (11a,b), and D-glucuronolactone (14) with 1 gave hydrazone…

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1 Haruo Ogura Kitasato University (JP) —
2 Hiroshi Takahashi Kitasato University (JP)
3 Masakazu Sakaguchi Kitasato University (JP) —
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