ROS-induced mitochondrial depolarization initiates PARK2/PAR…
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- DOI 10.4161/auto.21211
- PMID https://pubmed.ncbi.nlm.nih.gov/22889933
- OpenAlex ID W2009734791
- Type Article
- Language EN
- Published 13 Aug 2012
- Volume 8 (10)
- Pages 1462–1476
- Source Autophagy
- Publisher Taylor & Francis
- FWCI 18.61
- Countries 2
- Institutions 3
- Added 10 Oct 2025
- Updated 08 Oct 2026
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ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy
Article 2012 EN Hybrid
Reactive oxygen species (ROS) have been implicated as a signal for general autophagy. Both mitochondrial-produced and exogenous ROS induce autophagosome formation. However, it is unclear whether ROS are required for the selective autophagic degradation of mitochondria, a process called mitophagy. Recent work using carbonyl cyanide m-chlorophenylhydrazone (CCCP), a mitochondrial-uncoupling reagent,…
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1 SDGsAuthors & Affiliations
5 authors| # | Author | Institutions | ORCID |
|---|---|---|---|
| 1 | Yuqing Wang | University of Toronto (CA) Great Ormond Street Hospital (GB) +1 | |
| 2 | Yulia Nartiss | University of Toronto (CA) Great Ormond Street Hospital (GB) +1 | — |
| 3 | Boris Steipe | University of Toronto (CA) | |
| 4 | G. Angus McQuibban Corresponding | University of Toronto (CA) | |
| 5 | Peter Kijun Kim Corresponding | University of Toronto (CA) Great Ormond Street Hospital (GB) +1 |
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