A Combination of 3D-QSAR Modeling and Molecular Docking Appr…

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A Combination of 3D-QSAR Modeling and Molecular Docking Approach for the Discovery of Potential HIF Prolyl Hydroxylase Inhibitors

Article 2013 EN

Suppression of HIF prolyl hydroxylase (PHD) activity by small molecule inhibitors leads to the stabilization of HIF and offers a potential therapeutic option for treating ischemic disorders. In this study, pharmacophore based QSAR modeling, virtual screening and molecular docking approaches were concurrently used to identify target-specific PHD inhibitors with better ADME properties and to readily…

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1 Mahesh Kumar Teli National Institute of Technolo… (IN)
2 Golgodu Krishnamurthy Rajanikant Corresponding National Institute of Technolo… (IN)

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