Secretory activity in isolated rat stomach ECL cells

ECL cells are endocrine/paracrine cells located in the acid-producing part of the stomach. They are important regulators of gastric acid secretion in the stomach by virtue of their histamine synthesizing and secreting capacity. Histamine in turn stimulates parietal cells to secrete acid. The ECL cell also contains the endocrine polypeptide chromogranin A (CGA) and CGA-derived peptides such as panc…