Is Clathrin Required for Bulk Endocytosis

Key features of clathrin-associated endocytosis are outlined, and current evidence in favor of clathrin-independent endocytosis and of its structural counterpart(s) is reviewed. We next summarize our recent observations on clathrin-independent endocytosis in primary cultures of rat foetal fibroblasts, using two reversible inhibitors of the formation of endocytic clathrin-coated pits, Severe inhibi…