In Vitro Stimulation and Expansion of Human Tumour‐Reactive …

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In Vitro Stimulation and Expansion of Human Tumour‐Reactive CD8+ Cytotoxic T Lymphocytes by Anti‐CD3/CD28/CD137 Magnetic Beads

Article 2011 EN Bronze

Adoptive immunotherapy with tumour-reactive CD8(+) cytotoxic T lymphocytes (CTLs) requires efficient in vitro approaches allowing the expansion of CTLs to large numbers prior infusion. Here, we investigated the antigen-independent activation and the expansion of human T cells in peripheral blood mononuclear cells (PBMCs) and in tumour-reactive CTLs using Dynabeads coated with monoclonal antibodies…

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8 authors
#AuthorInstitutionsORCID
1 Daniel Teschner Johannes Gutenberg University … (DE) University Medical Center of t… (DE)
2 Gregor Wenzel Johannes Gutenberg University … (DE) University Medical Center of t… (DE) —
3 E. Distler Johannes Gutenberg University … (DE) University Medical Center of t… (DE)
4 Elke Schnürer Johannes Gutenberg University … (DE) University Medical Center of t… (DE) —
5 M. Theobald Johannes Gutenberg University … (DE) University Medical Center of t… (DE) —
6 Axl A. Neurauter —
7 Karoline W. Schjetne —
8 W. Herr Corresponding Johannes Gutenberg University … (DE) University Medical Center of t… (DE) —

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